Gel Permeation Chromatography (GPC) Market Overview, Analysis and Regional Insights
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Gel Permeation Chromatography Market |
The size
exclusion technique of gel permeation chromatography is used to separate and
characterise polymers. It is a one-of-a-kind technique for determining the
molecular weight distribution of an analyte using polymer characterisation. The
polymer's profile is significant because it affects physical qualities
including brittleness, elasticity, and toughness in its final application. The
premise behind the gel permeation chromatography system is that various
components have variable affinity for the stationary phase (Column Packing
material). Smaller components become caught in the pores of the packing
material, resulting in a long retention duration. Larger components in
analytes, on the other hand, pass through the stationary phase without
significant affinity, resulting in a shorter retention duration. Based on this
information, the processing unit displays various peaks on the display that can
be used for cauterization and separation of the analyte. Pump, injector,
columns, detectors, and data processing systems are among the components of a
gel permeation chromatography system.
Increasing research and development
by pharmaceutical and biotech companies in chronic disease is expected to
propel growth of the gel permeation chromatography market
The Gel
Permeation Chromatography (GPC) Market is predicted to rise as pharmaceutical and biotech
businesses around the world focus more on research and development operations
to deliver novel medicines to chronic diseases like cancer. CAR-T cell therapy,
antibody-drug conjugates, and immunological check point inhibitors are examples
of protein (Natural Polymer) based therapeutics. According to a survey
published by the International Federation of Pharmaceutical Manufacturers and
Associations in 2017, research-based pharmaceutical and biotech companies spend
roughly US$ 149 billion on R&D each year. Over 7,000 molecules are being
studied, with around 2,000 of them being cancer candidates. As a result, gel
permeation chromatography can effectively separate and characterise new
chemical entities that are polymer-based, which is projected to boost market
expansion in the near future. Furthermore, the majority of the drugs under
investigation are in the preclinical stage, which entails studying the structure
and components of a novel chemical entity, which necessitates the use of the
GPC system.
Regulatory approvals for use of novel
excipients (Polymers) is expected to drive growth of the gel permeation
chromatography market
Polymers are
frequently used as an excipient (binder, diluent, coating agents, suspending
agent, viscosity agent, and disintegrant) by pharmaceutical and biotech
businesses to provide a range of dosage forms. Natural polymers are
increasingly being used instead of synthetic ones due to their inertness, low
cost, and increased customer acceptance of natural polymers. Solutol HS 15,
Soluplus, Kollicoat Smartseal 30 D, Polyplasdone Ultra, and Prosolv ODT are
some of the natural polymers that have lately been released by various firms.
However, end users (pharmaceutical and biotech businesses) must be confident in
the quality of polymers used as excipients before utilising them in
formulations. In the production of the formulations, the USFDA requires Quality
by Design (non-adherence otherwise leads to product recalls). As a result,
organisations must test these polymers for quality factors.
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